Stem-Loss in Cancer Therapy Treated With New Discovery
September 7, 2010 |15:34 | Biology By : Team X
Chemotherapy or radiation therapy leads to loss of stem cells that ends in anaemia, appetite and weight loss in cancer patients. The loss of adult stem cells is particularly dangerous, as they are the ones responsible for making new blood and intestine cells. Scientists have long known that during cancer therapy, the tumour suppressor p53 is activated, which leads cells to stop dividing, go into hibernation and undergo a programmed cell death called apoptosis.
They've also known that a gene called Puma is critical for p53 to initiate the cell death of DNA-damaged cells, reports Nature. "You can target Puma to prevent p53-mediated depletion of adult stem cells, because a Puma deficiency does not promote the development of cancer," said Yang Xu at UC San Diego.
"If you can suppress Puma function, you can rescue a lot of the adult stem cells that would otherwise be lost after the accumulation of DNA damage such as during cancer therapy," he added. The team published its findings in this week's advance online issue of the journal Nature Cell Biology.
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The University of Texas at San Antonio (UTSA) South Texas Center Emerging Infectious Diseases (STCEID), and Bernard Arulanandam, associate dean of research for scientific innovation in.
They exhibit remarkable properties. They never complain. And you can kill off the ones you don't like at the end of the day. Those are just three of the reasons why genetically modified microorganisms could become some of.













